, a bacterium found in the human microbiota, has gained interest due to its potential health benefits. Previous studies have linked its absence to inflammatory disorders, while also suggesting its role in maintaining a healthy gut barrier. However, there is limited information on its specific effects on the immune system. Therefore, the aim of this research was to analyze the response triggered by employing RAW 264.7 macrophages. The study focused on investigating the production of cytokines and nitric oxide, along with evaluating the expression of inflammatory surface cellular markers. Additionally, we assessed its potential to protect against intestinal infections, using serovar Enteritidis as a model. Our findings reveal a modulation effect of with pro-inflammatory features, including the release of pro-inflammatory cytokines and upregulation of CD40 and CD80 surface markers, in contrast with previous reported data. Importantly, could protect against infection by promoting macrophage activation, appearing as a promising probiotic candidate for the control of intestinal infections.

中文翻译：

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揭示新型益生菌 Akkermansia muciniphila 的免疫调节作用及其体外保护作用

人类微生物群中发现的一种细菌，由于其潜在的健康益处而引起了人们的兴趣。先前的研究已将其缺乏与炎症性疾病联系起来，同时也表明其在维持健康的肠道屏障方面的作用。然而，关于其对免疫系统的具体影响的信息有限。因此，本研究的目的是分析使用 RAW 264.7 巨噬细胞引发的反应。该研究的重点是研究细胞因子和一氧化氮的产生，以及评估炎症表面细胞标志物的表达。此外，我们使用肠炎血清型作为模型，评估了其预防肠道感染的潜力。我们的研究结果揭示了促炎特征的调节作用，包括促炎细胞因子的释放以及 CD40 和 CD80 表面标记物的上调，与之前报道的数据相反。重要的是，可以通过促进巨噬细胞活化来防止感染，成为控制肠道感染的有前途的益生菌候选者。