Degradable biomedical elastomers (DBE), characterized by controlled biodegradability, excellent biocompatibility, tailored elasticity, and favorable network design and processability, have become indispensable in tissue repair. This review critically examines the recent advances of biodegradable elastomers for tissue repair, focusing mainly on degradation mechanisms and evaluation, synthesis and crosslinking methods, microstructure design, processing techniques, and tissue repair applications. The review explores the material composition and cross-linking methods of elastomers used in tissue repair, addressing chemistry-related challenges and structural design considerations. In addition, this review focuses on the processing methods of two- and three-dimensional structures of elastomers, and systematically discusses the contribution of processing methods such as solvent casting, electrostatic spinning, and three-/four-dimensional printing of DBE. Furthermore, we describe recent advances in tissue repair using DBE, and include advances achieved in regenerating different tissues, including nerves, tendons, muscle, cardiac, and bone, highlighting their efficacy and versatility. The review concludes by discussing the current challenges in material selection, biodegradation, bioactivation, and manufacturing in tissue repair, and suggests future research directions. This concise yet comprehensive analysis aims to provide valuable insights and technical guidance for advances in DBE for tissue engineering.

中文翻译：

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可降解生物医用弹性体：为组织修复和再生医学的未来铺平道路

可降解生物医用弹性体（DBE）具有可控的生物降解性、优异的生物相容性、定制的弹性以及良好的网络设计和加工性能，已成为组织修复中不可或缺的材料。本综述批判性地审视了用于组织修复的生物可降解弹性体的最新进展，主要关注降解机制和评估、合成和交联方法、微观结构设计、加工技术和组织修复应用。该综述探讨了用于组织修复的弹性体的材料成分和交联方法，解决了化学相关的挑战和结构设计考虑因素。此外，本文重点讨论了弹性体二维和三维结构的加工方法，系统地讨论了DBE的溶剂浇铸、静电纺丝和三/四维打印等加工方法的贡献。此外，我们描述了使用 DBE 进行组织修复的最新进展，包括在再生不同组织（包括神经、肌腱、肌肉、心脏和骨骼）方面取得的进展，强调了它们的功效和多功能性。该综述最后讨论了组织修复中材料选择、生物降解、生物活化和制造方面当前面临的挑战，并提出了未来的研究方向。这一简洁而全面的分析旨在为组织工程 DBE 的进展提供有价值的见解和技术指导。