ObjectiveThe objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.MethodsIn a prospective birth cohort of Dominican and African American children from New York City, New York (1998–2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed‐effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age2 were used to assess associations between age and adiposity trajectories.ResultsBMI was, on average, 1.5 kg/m2 higher (95% CI: 0.58, 2.5) in individuals with mtDNAcn in the low‐ compared with the middle‐mtDNAcn tertile. Results were similar for BMI z score, fat mass index, and body fat percentage. Moreover, children in the low‐mtDNAcn group had increased odds of being in an “increasing” or “high‐stable” adiposity class.ConclusionsLower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.

中文翻译：

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脐带血线粒体 DNA 拷贝数与儿童肥胖呈负相关

目的本研究的目的是检查脐带线粒体 DNA 拷贝数 (mtDNAcn) 与整个童年时期肥胖之间的关联。方法在来自纽约州纽约市 (1998-2006) 的多米尼加和非洲裔美国儿童的前瞻性出生队列中，mtDNAcn在脐带血中测量。孩子们 （氮= 336）在 5、7、9 和 11 岁时评估了他们的身高、体重和生物阻抗。我们使用线性混合效应模型来评估脐带血中 mtDNAcn 三分位数与儿童 BMI、BMI 的关联z分数、脂肪质量指数和体脂百分比。潜在阶级增长模型以及 mtDNAcn 与儿童年龄或儿童年龄之间的相互作用2用于评估年龄和肥胖轨迹之间的关联。结果BMI 平均为 1.5 kg/m2与中等 mtDNAcn 三分位相比，mtDNAcn 处于低位的个体更高（95% CI：0.58，2.5）。BMI 的结果相似z分数、脂肪质量指数和体脂百分比。此外，低 mtDNAcn 组的儿童处于“增加”或“高稳定”肥胖类别的几率增加。结论 出生时 mtDNAcn 较低可能预示儿童期肥胖程度更高，这凸显了围产期线粒体功能在肥胖中的潜在关键作用。发展。