Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells – a critical component of the aging process – undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.

中文翻译：

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癌症和衰老中的代谢重塑及其治疗意义

细胞代谢是一个灵活的可塑网络，通常决定细胞的生理和病理状态，包括分化、癌症和衰老。癌症代谢的最新进展代表了通过靶向代谢改变来治疗癌症的巨大机会。有趣的是，尽管衰老细胞的生长稳定停滞，但衰老细胞（衰老过程的关键组成部分）会经历与癌症代谢类似的代谢变化。更深入地了解这些不同病理状况之间的相似性和差异将有助于确定哪种代谢重编程与衰老的治疗作用最相关。在这里，我们比较和对比癌症和衰老代谢，并讨论如何将代谢疗法建立为健康衰老的新衰老疗法方式。