Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis,Schizophrenia Bulletin

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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Schizophrenia Bulletin ( IF 6.6 ) Pub Date : 2024-03-07 , DOI: 10.1093/schbul/sbae011
Cassandra M J Wannan _{1,

2} , Barnaby Nelson _{1,

2} , Jean Addington ₃ , Kelly Allott _{1,

2} , Alan Anticevic _{4,

5} , Celso Arango ₆ , Justin T Baker ₇ , Carrie E Bearden _{8,

9} , Tashrif Billah ₁₀ , Sylvain Bouix ₁₁ , Matthew R Broome _{12,

13} , Kate Buccilli _{1,

2} , Kristin S Cadenhead ₁₄ , Monica E Calkins ₁₅ , Tyrone D Cannon _{4,

16} , Guillermo Cecci ₁₇ , Eric Yu Hai Chen ₁₈ , Kang Ik K Cho ₉ , Jimmy Choi ₁₉ , Scott R Clark _{20,

21} , Michael J Coleman ₉ , Philippe Conus ₂₂ , Cheryl M Corcoran ₂₃ , Barbara A Cornblatt _{24,

25} , Covadonga M Diaz-Caneja ₆ , Dominic Dwyer _{1,

2} , Bjørn H Ebdrup ₂₆ , Lauren M Ellman ₂₇ , Paolo Fusar-Poli _{28,

29} , Liliana Galindo _{30,

31} , Pablo A Gaspar ₃₂ , Carla Gerber ₃₃ , Louise Birkedal Glenthøj _{34,

35} , Robert Glynn _{36,

37} , Michael P Harms ₃₈ , Leslie E Horton ₃₉ , René S Kahn ₂₃ , Joseph Kambeitz ₄₀ , Lana Kambeitz-Ilankovic ₄₀ , John M Kane _{24,

25} , Tina Kapur ₄₁ , Matcheri S Keshavan ₄₂ , Sung-Wan Kim _{43,

44} , Nikolaos Koutsouleris ₄₅ , Marek Kubicki _{9,

46} , Jun Soo Kwon _{47,

48} , Kerstin Langbein ₄₉ , Kathryn E Lewandowski ₇ , Gregory A Light _{14,

50} , Daniel Mamah ₅₁ , Patricia J Marcy ₅₂ , Daniel H Mathalon _{53,

54} , Patrick D McGorry _{1,

2} , Vijay A Mittal ₅₅ , Merete Nordentoft _{34,

56} , Angela Nunez _{4,

5} , Ofer Pasternak _{9,

46} , Godfrey D Pearlson _{4,

19} , Jesus Perez _{57,

58} , Diana O Perkins ₅₉ , Albert R Powers _{4,

5} , David R Roalf ₁₅ , Fred W Sabb ₆₀ , Jason Schiffman ₆₁ , Jai L Shah _{62,

63} , Stefan Smesny ₄₉ , Jessica Spark _{1,

2} , William S Stone ₄₂ , Gregory P Strauss ₆₄ , Zailyn Tamayo _{4,

5} , John Torous ₄₃ , Rachel Upthegrove _{11,

65} , Mark Vangel ₆₆ , Swapna Verma ₆₇ , Jijun Wang ₆₈ , Inge Winter-van Rossum ₂₅ , Daniel H Wolf ₁₅ , Phillip Wolff ₆₉ , Stephen J Wood _{1,

2,

70} , Alison R Yung _{71,

72} , Carla Agurto ₁₇ , Mario Alvarez-Jimenez _{1,

2} , Paul Amminger _{1,

2} , Marco Armando ₇₃ , Ameneh Asgari-Targhi ₄₁ , John Cahill _{4,

5} , Ricardo E Carrión _{24,

25} , Eduardo Castro ₁₇ , Suheyla Cetin-Karayumak ₉ , M Mallar Chakravarty ₆₃ , Youngsun T Cho _{4,

5} , David Cotter _{74,

75} , Simon D’Alfonso ₇₆ , Michaela Ennis ₇ , Shreyas Fadnavis ₉ , Clara Fonteneau _{4,

5} , Caroline Gao _{1,

2} , Tina Gupta ₃₉ , Raquel E Gur ₁₅ , Ruben C Gur ₁₅ , Holly K Hamilton ₁₀ , Gil D Hoftman _{8,

9} , Grace R Jacobs ₁₀ , Johanna Jarcho ₂₇ , Jie Lisa Ji _{4,

5} , Christian G Kohler ₁₅ , Paris Alexandros Lalousis _{12,

77} , Suzie Lavoie _{1,

2} , Martin Lepage ₆₃ , Einat Liebenthal ₇₈ , Josh Mervis ₂₇ , Vishnu Murty ₂₇ , Spero C Nicholas ₅₁ , Lipeng Ning _{9,

41} , Nora Penzel ₉ , Russell Poldrack ₇₉ , Pablo Polosecki ₁₇ , Danielle N Pratt ₅₅ , Rachel Rabin ₆₂ , Habiballah Rahimi Eichi ₇ , Yogesh Rathi _{10,

41} , Avraham Reichenberg ₂₃ , Jenna Reinen ₁₇ , Jack Rogers ₇₇ , Bernalyn Ruiz-Yu ₈ , Isabelle Scott _{1,

2} , Johanna Seitz-Holland ₁₀ , Vinod H Srihari _{4,

78} , Agrima Srivastava ₂₃ , Andrew Thompson _{1,

2} , Bruce I Turetsky ₁₅ , Barbara C Walsh _{4,

5} , Thomas Whitford _{2,

80} , Johanna T W Wigman ₈₁ , Beier Yao ₇ , Hok Pan Yuen _{1,

2} , Uzair Ahmed ₂ , Andrew (Jin Soo) Byun _{82,

83} , Yoonho Chung ₇ , Kim Do _{84,

85} , Larry Hendricks _{1,

2} , Kevin Huynh _{1,

2} , Clark Jeffries ₈₆ , Erlend Lane ₄₂ , Carsten Langholm ₄₂ , Eric Lin _{7,

87,

88} , Valentina Mantua ₈₉ , Gennarina Santorelli ₄₃ , Kosha Ruparel ₁₆ , Eirini Zoupou ₁₆ , Tatiana Adasme ₃₂ , Lauren Addamo _{1,

2} , Laura Adery _{8,

9} , Munaza Ali _{4,

5} , Andrea Auther ₂₄ , Samantha Aversa ₆₂ , Seon-Hwa Baek _{43,

44} , Kelly Bates ₅₅ , Alyssa Bathery ₈₉ , Johanna M M Bayer _{1,

2} , Rebecca Beedham _{1,

2} , Zarina Bilgrami ₆₉ , Sonia Birch _{1,

2} , Ilaria Bonoldi _{28,

29} , Owen Borders ₁₀ , Renato Borgatti _{29,

90} , Lisa Brown ₄₁ , Alejandro Bruna ₃₂ , Holly Carrington ₁₀ , Rolando I Castillo-Passi _{32,

91} , Justine Chen ₁₀ , Nicholas Cheng _{1,

2} , Ann Ee Ching _{1,

2} , Chloe Clifford ₁₂ , Beau-Luke Colton _{1,

2} , Pamela Contreras ₃₂ , Sebastián Corral ₃₂ , Stefano Damiani ₂₉ , Monica Done _{8,

9} , Andrés Estradé ₉₂ , Brandon Asika Etuka ₄ , Melanie Formica _{1,

2} , Rachel Furlan ₂₇ , Mia Geljic _{1,

2} , Carmela Germano _{1,

2} , Ruth Getachew _{1,

2} , Mathias Goncalves ₇₉ , Anastasia Haidar ₁₀ , Jessica Hartmann ₉₃ , Anna Jo ₄₃ , Omar John ₁₀ , Sarah Kerins ₉₂ , Melissa Kerr _{1,

2} , Irena Kesselring ₈₉ , Honey Kim ₄₃ , Nicholas Kim ₁₀ , Kyle Kinney ₂₇ , Marija Krcmar _{1,

2} , Elana Kotler ₁₀ , Melanie Lafanechere _{70,

77} , Clarice Lee _{1,

2} , Joshua Llerena _{1,

2} , Christopher Markiewicz ₇₉ , Priya Matnejl ₅₂ , Alejandro Maturana ₃₂ , Aissata Mavambu ₁₂ , Rocío Mayol-Troncoso ₃₂ , Amelia McDonnell ₂₇ , Alessia McGowan ₂₃ , Danielle McLaughlin ₅₂ , Rebecca McIlhenny ₃₉ , Brittany McQueen _{1,

2} , Yohannes Mebrahtu _{1,

2} , Martina Mensi _{29,

90} , Christy Lai Ming Hui ₁₈ , Yi Nam Suen ₁₈ , Stephanie Ming Yin Wong ₁₈ , Neal Morrell _{1,

2} , Mariam Omar _{1,

2} , Alice Partridge _{1,

2} , Christina Phassouliotis _{1,

2} , Anna Pichiecchio _{29,

94} , Pierluigi Politi ₂₉ , Christian Porter ₃₉ , Umberto Provenzani ₂₉ , Nicholas Prunier ₁₀ , Jasmine Raj ₅₅ , Susan Ray ₅₂ , Victoria Rayner _{1,

2} , Manuel Reyes _{32,

91} , Kate Reynolds _{1,

2} , Sage Rush ₈₉ , Cesar Salinas ₃₂ , Jashmina Shetty _{1,

2} , Callum Snowball _{1,

2} , Sophie Tod _{1,

2} , Gabriel Turra-Fariña ₃₂ , Daniela Valle ₃₂ , Simone Veale ₁₀ , Sarah Whitson _{1,

2} , Alana Wickham ₁₀ , Sarah Youn _{1,

2} , Francisco Zamorano _{95,

96} , Elissa Zavaglia ₆₂ , Jamie Zinberg _{8,

9} , Scott W Woods _{4,

5} , Martha E Shenton _{10,

41,

46}

Affiliation

Centre for Youth Mental Health, The University of Melbourne , Parkville, VIC , Australia
Orygen , Parkville, VIC , Australia
Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada
Department of Psychiatry, Yale University School of Medicine , New Haven, CT , USA
Connecticut Mental Health Center , New Haven, CT , USA
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense , Madrid , Spain
Department of Psychiatry, McLean Hospital and Harvard Medical School , Boston, MA , USA
Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA , USA
Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA , USA
Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School , Boston, MA , USA
Department of Software Engineering and Information Technology, École de technologie supérieure , Montréal , Canada
School of Psychology, Institute for Mental Health, University of Birmingham , Birmingham , UK
Early Intervention for Psychosis Services, Birmingham Women’s and Children’s NHS Foundation Trust , Birmingham , UK
Department of Psychiatry, University of California, San Diego , CA , USA
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA
Department of Psychology, Yale University , New Haven, CT , USA
IBM T.J. Watson Research Center , Yorktown Heights, NY , USA
Department of Psychiatry, University of Hong Kong , Pok Fu Lam , Hong Kong
Olin Neuropsychiatry Research Center, Hartford Hospital , Hartford, CT , USA
Discipline of Psychiatry, University of Adelaide , Adelaide, SA , Australia
Basil Hetzel Institute , Woodville, SA , Australia
General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland
Department of Psychiatry, Icahn School of Medicine at Mount Sinai , New York, NY , USA
Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell , Hempstead, NY , USA
Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health , Manhasset, NY , USA
Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup , Copenhagen , Denmark
Department of Psychology and Neuroscience, Temple University , Philadelphia, PA , USA
Department of Psychosis Studies, King’s College London , London , UK
Department of Brain and Behavioral Sciences, University of Pavia , Pavia , Italy
Cambridgeshire and Peterborough NHS Foundation Trust , Cambridge , UK
Department of Psychiatry, University of Cambridge , Cambridge , UK
Department of Psychiatry, IMHAY, University of Chile , Santiago , Chile
Behavioral Health Services, PeaceHealth Medical Group , Eugene, OR , USA
Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen , Denmark
Department of Psychology, University of Copenhagen , Copenhagen , Denmark
Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA , USA
Department of Biostatistics, Harvard T.H. Chan School of Public Health and Harvard Medical School , Boston, MA , USA
Department of Psychiatry, Washington University School of Medicine , St. Louis, MO , USA
Department of Psychiatry, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA
Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany
Department of Radiology, Brigham and Women’s Hospital , Boston, MA , USA
Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA , USA
Department of Psychiatry, Chonnam National University Medical School , Gwangju , Korea
Mindlink, Gwangju Bukgu Mental Health Center , Gwangju , Korea
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich , Munich , Germany
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA
Department of Psychiatry, Seoul National University College of Medicine , Seoul , Korea
Department of Neuropsychiatry, Seoul National University Hospital , Seoul , Korea
Department of Psychiatry and Psychotherapy, Jena University Hospital , Jena , Germany
Veterans Affairs San Diego Health Care System , San Diego, CA , USA
Department of Psychiatry, Washington University Medical School , St. Louis, MO , USA
Northwell Health , Glen Oaks, NY , USA
Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco , San Francisco, CA , USA
Mental Health Service 116D, Veterans Affairs San Francisco Health Care System , San Francisco, CA , USA
Department of Psychology, Northwestern University , Evanston, IL , USA
Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark
CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust , Cambridge , UK
Department of Medicine, Institute of Biomedical Research (IBSAL), Universidad de Salamanca , Salamanca , Spain
Department of Psychiatry, University of North Carolina at Chapel Hill , Chapel Hill, NC , USA
Prevention Science Institute, University of Oregon , Eugene, OR , USA
Department of Psychological Science, University of California, Irvine , Irvine, CA , USA
PEPP-Montreal, Douglas Research Centre , Montreal, Quebec , Canada
Department of Psychiatry, McGill University , Montreal, Quebec , Canada
Department of Psychology, University of Georgia , Athens, GA , USA
Birmingham Womens and Childrens, NHS Foundation Trust , Birmingham , UK
Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA
Department of Psychosis, Institute of Mental Health , Singapore
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine , Shanghai , China
Department of Psychology, Emory University , Atlanta, GA , USA
School of Psychology, University of Birmingham , Edgbaston , UK
Institute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University , Geelong, VIC , Australia
School of Health Sciences, University of Manchester , Manchester , UK
Youth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne , Lausanne , Switzerland
Department Psychiatry, Beaumont Hospital , Dublin 9 , Ireland
Department of Psychiatry, Royal College of Surgeons in Ireland , Dublin 2 , Ireland
School of Computing and Information Systems, The University of Melbourne , Parkville, VIC , Australia
Centre for Human Brain Health, School of Psychology, University of Birmingham , Birmingham , UK
Program for Specialized Treatment Early in Psychosis (STEP), CMHC , New Haven, CT , USA
Department of Psychology, Stanford University , Stanford, CA , USA
School of Psychology, University of New South Wales (UNSW) , Kensington, NSW , Australia
Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen , Netherlands
Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA
John A. Paulson School of Engineering and Applied Sciences, Harvard University , Cambridge, MA , USA
Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL) , Lausanne , Switzerland
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King’s College London , London , UK
Renaissance Computing Institute, University of North Carolina , Chapel Hill, NC , USA
Medical Informatics Fellowship, Veteran Affairs Boston Healthcare System , Boston, MA , USA
Food and Drug Administration , Silver Spring, MD , USA
Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania , Philadelphia, PA , USA
IRCCS Mondino Foundation , Pavia , Italy
Department of Neurology and Psychiatry, Clínica Alemana—Universidad del Desarrollo , Santiago , Chile
Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King’s College London , London , UK
Department of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy , Mannheim , Germany
Neuroradiology Department, IRCCS Mondino Foundation , Pavia , Italy
Unidad de imágenes cuantitativas avanzadas, departamento de imágenes, clínica alemana, universidad del Desarrollo , Santiago , Chile
Facultad de ciencias para el cuidado de la salud, Universidad San Sebastián, Campus Los Leones , Santiago , Chile

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

中文翻译：

Acceleating Medicines Partnership® 精神分裂症 (AMP® SCZ)：全球最大的精神病临床高风险前瞻性队列研究的基本原理和研究设计

本文介绍了 Accelerated Medicines Partnership® 精神分裂症 (AMP® SCZ) 的基本原理、目标和方法。这是迄今为止规模最大的国际合作，将开发算法来预测精神病临床高风险 (CHR) 个体的轨迹和结果，并推动针对 CHR 个体的新型药物干预措施的开发和使用。我们介绍了参与的研究网络以及数据处理分析和协调中心、来自 13 个参与国家的 43 个站点的数据协调流程（横跨北美、澳大利亚、欧洲、亚洲和南美的招聘）、数据流和质量评估流程、数据分析以及将数据传输到国家心理健康研究所 (NIMH) 数据档案 (NDA) 供研究界使用。在大约 2000 名 CHR 个体和 640 名匹配的健康对照的预期样本中，AMP SCZ 将收集临床、环境和认知数据以及多模式生物标志物，包括神经影像、电生理学、液体生物样本、言语和面部表情样本、源自数字的新测量方法健康技术，包括基于智能手机的日常调查、被动传感以及体动记录仪。该研究将调查两年内的一系列临床结果，包括向精神病的转变、CHR状态的缓解或持续、阳性症状减弱、阴性症状持续、情绪和焦虑症状以及心理社会功能。AMP SCZ 的全球影响力及其协调一致的创新方法有望促进新疗法的开发，以满足 CHR 个体未满足的关键临床和公共卫生需求。

更新日期：2024-03-07

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