For decades, the unwritten rule for asthma management was ‘Keep it Simple’, with clinicians largely trying to apply a one-size-fits-all stepwise approach to hundreds of millions of people across the globe. More recently, our broader understanding, increasing array of targeted therapies, and relatively stagnant outcomes have led to a greater acknowledgement of the complexity that needs to be addressed.1 However, despite progress, our therapeutic pathways do not account for some basic patient characteristics such as sex. The impacts of sex and gender on asthma pathogenesis, prevalence and manifestation throughout life have been studied to some degree, but the study by Loewenthal et al in this issue of Thorax 2 focusing on severe asthma is a welcome addition to the literature. The authors have used the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) to evaluate sex differences in disease characteristics, symptom control, exacerbations, core biological phenotypes and treatment in patients with severe asthma using a retrospective epidemiological approach.2 They found that women report a greater symptom burden despite having better lung function and inflammatory profiles compared with males. This finding was apparent in mild, moderate or severe asthma. It is well recognised that men …

中文翻译：

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性别和性别对严重哮喘的影响

几十年来，哮喘管理的不成文规则是“保持简单”，临床医生主要试图对全球数亿人采用一种一刀切的逐步方法。最近，我们更广泛的理解、越来越多的靶向治疗以及相对停滞的结果使我们更加认识到需要解决的复杂性。1然而，尽管取得了进展，我们的治疗途径并没有考虑到一些基本的患者特征，例如作为性。性别和性别对哮喘发病机制、患病率和一生表现的影响已在一定程度上进行了研究，但 Loewenthal 等人在本期 Thorax 2 中针对严重哮喘的研究是对文献的一个值得欢迎的补充。作者利用英国严重哮喘登记处 (UKSAR) 和最佳患者护理研究数据库 (OPCRD)，采用回顾性流行病学方法评估严重哮喘患者在疾病特征、症状控制、恶化、核心生物表型和治疗方面的性别差异。 2 他们发现，尽管女性的肺功能和炎症状况比男性更好，但她们的症状负担却更大。这一发现在轻度、中度或重度哮喘中很明显。众所周知，男人...