Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.

中文翻译：

---

脂滴和细胞脂质通量

脂滴是动态细胞器，可储存中性脂质，满足细胞的代谢需求，并隔离脂质以防止脂毒性和膜损伤。在这里，我们回顾了目前对脂滴生物发生和周转机制、脂质和代谢物在膜接触位点的转移以及脂滴在脂毒性和细胞死亡中调节脂肪酸通量的作用的理解。