Dengue represents an increasing public health burden worldwide. In Africa, underreporting and misdiagnosis often mask its true epidemiology, and dengue is likely to be both more widespread than reported data suggest and increasing in incidence and distribution. Wolbachia‐based dengue control is underway in Asia and the Americas but has not to date been deployed in Africa. Due to the genetic heterogeneity of African Aedes aegypti populations and the complexity of the host‐symbiont interactions, characterization of key parameters of Wolbachia‐carrying mosquitoes is paramount for determining the potential of the system as a control tool for dengue in Africa. The wAlbB Wolbachia strain was stably introduced into an African Ae. aegypti population by introgression, and showed high intracellular density in whole bodies and different mosquito tissues; high intracellular density was also maintained following larval rearing at high temperatures. No effect on the adult lifespan induced by Wolbachia presence was detected. Moreover, the ability of this strain to strongly inhibit DENV‐2 dissemination and transmission in the host was also demonstrated in the African background. Our findings suggest the potential of harnessing Wolbachia for dengue control for African populations of Ae. aegypti.

中文翻译：

---

沃尔巴克氏菌菌株 wAlbB 显示出用于布基纳法索埃及伊蚊登革热控制的有利特性

登革热在全世界范围内造成了日益严重的公共卫生负担。在非洲，漏报和误诊往往掩盖了其真实的流行病学，登革热可能比报告的数据显示的更为广泛，而且发病率和分布范围也在增加。沃尔巴克氏体基于登革热的控制措施正在亚洲和美洲进行，但迄今为止尚未在非洲部署。由于非洲人的遗传异质性埃及伊蚊种群和宿主-共生体相互作用的复杂性，关键参数的表征沃尔巴克氏体‐携带蚊子对于确定该系统作为非洲登革热控制工具的潜力至关重要。这w白蛋白B沃尔巴克氏体菌株被稳定引入非洲艾。埃及伊蚊通过基因渗入的方式种群，并在整个身体和不同的蚊子组织中表现出高细胞内密度；在高温下培育幼体后，细胞内密度也保持较高。对成人寿命无影响沃尔巴克氏体检测到存在。此外，该菌株强烈抑制DENV-2在宿主体内传播和传播的能力也在非洲背景中得到证实。我们的研究结果表明了利用的潜力沃尔巴克氏体为非洲人口控制登革热艾。埃及伊蚊。