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Hijacking endogenous mRNA for genetic code expansion
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2024-03-07 , DOI: 10.1038/s41589-024-01574-9
Tomohiro Doura , Yuma Matsuoka , Shigeki Kiyonaka

Labeling of endogenous proteins with chemical probes is highly desirable for life science studies. The combination of RNA base editing and site-specific incorporation of non-canonical amino acids allows the introduction of small chemical tags into endogenous proteins in living cells.

中文翻译:

劫持内源 mRNA 进行遗传密码扩展

用化学探针标记内源蛋白质对于生命科学研究来说是非常理想的。RNA 碱基编辑和非规范氨基酸的位点特异性掺入相结合,可以将小的化学标签引入活细胞的内源蛋白质中。
更新日期:2024-03-07
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