ObjectiveThe study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.MethodsAll 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events was observed for 11 years. The main outcome was 3‐point major adverse cardiac events (MACE), which comprises cardiovascular death, nonfatal coronary artery disease, and nonfatal stroke incidence.ResultsOf the participants, 2748 (2.3%) cases of 3‐point MACE were identified during follow‐up. The stable metabolically healthy obesity group had a higher risk of 3‐point MACE than those with stable metabolically healthy nonobesity (MHNO). Additionally, the change from metabolically healthy obesity to MHNO for 2 years decreased the risk of 3‐point MACE (hazard ratio [HR], 1.12: 95% CI: 0.84–1.47) to the same level as stable MHNO. However, the change from metabolically abnormal nonobesity and metabolically abnormal obesity to MHNO for 2 years maintained a higher risk of 3‐point MACE (HR, 1.66 [95% CI: 1.36–2.01]; HR, 1.91 [95% CI: 1.22–2.81]) than those with stable MHNO.ConclusionsChange in metabolic phenotype is associated with incident 3‐point MACE.

中文翻译：

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代谢表型的转变和心血管事件：松下队列研究 16

目的研究目的是探讨代谢表型的变化是否影响心血管事件的风险。方法本回顾性队列研究纳入了全部117,589名参与者。对参与者的代谢表型进行两次评估（第二次评估设定在第一次评估后2年），并观察11年的心血管事件发生率。主要结局是 3 点主要不良心脏事件 (MACE)，包括心血管死亡、非致死性冠状动脉疾病和非致死性中风发生率。结果在参与者中，在随访期间发现了 2748 例 (2.3%) 3 点 MACE 病例。向上。稳定代谢健康肥胖组比稳定代谢健康非肥胖组 (MHNO) 发生 3 点 MACE 的风险更高。此外，从代谢健康肥胖改为 MHNO 2 年可将 3 点 MACE 风险（风险比 [HR]，1.12：95% CI：0.84–1.47）降低至与稳定 MHNO 相同的水平。然而，从代谢异常非肥胖和代谢异常肥胖转变为 MHNO 2 年仍保持较高的 3 点 MACE 风险（HR，1.66 [95% CI：1.36-2.01]；HR，1.91 [95% CI：1.22- 2.81]）高于稳定 MHNO 的患者。结论代谢表型的变化与发生的 3 点 MACE 相关。