Asymmetric organocatalysis has been recognized as one of the “top 10 emerging technologies” in chemistry by IUPAC in 2019. Its potential to make chemical processes more sustainable is promising, but there are still challenges that need to be addressed. Developing new and reliable enantioselective processes for reproducing batch reactions on a large scale requires a combination of chemical and technical solutions. In this manuscript, we combine a robust immobilized chiral phosphoric acid with a new packed-bed reactor design. This combination allows scaling up of the enantioselective addition of thiols to imines from a few milligrams to a multi-decagram scale in a continuous flow process without physical or chemical degradation of the catalyst.

中文翻译：

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强大的异质手性磷酸可实现数十克规模的光学活性 N,S-缩酮的生产

不对称有机催化被IUPAC评为2019年化学领域“十大新兴技术”之一。它使化学过程更加可持续的潜力是有前景的，但仍然存在需要解决的挑战。开发新的、可靠的对映选择性工艺来大规模重现间歇反应需要化学和技术解决方案的结合。在这份手稿中，我们将坚固的固定手性磷酸与新的填充床反应器设计相结合。这种组合允许在连续流动过程中将硫醇与亚胺的对映选择性加成规模从几毫克扩大到数十克规模，而不会导致催化剂的物理或化学降解。