Calcitonin gene-related peptide (CGRP) and histamine plasma concentrations increase during migraine attacks. Both mediators are potent vasodilators, and they have been shown to reciprocally contribute to the release of each other in the trigeminovascular system, possibly driving migraine development. A high-histamine-content diet triggers migraine in patients who have histamine degradation deficiency owing to diaminooxidase (DAO) gene mutations. Therefore, studying functional links between exogenous histamine and CGRP seems promising for the understanding of diet-induced migraine generation. Notably, there is a lack of knowledge about the interplay of the enteric nervous system and the spinal/trigeminal somatosensory system with regard to CGRP and histamine. Based on background evidence, we propose that a functional interconnection between exogenous histamine and CGRP contributes to migraine development.

中文翻译：

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降钙素基因相关肽（CGRP）是食物组胺诱发偏头痛的缺失环节吗？肠道与三叉血管系统功能连接的综述

偏头痛发作期间，降钙素基因相关肽（CGRP）和组胺血浆浓度增加。这两种介质都是有效的血管扩张剂，并且已被证明它们在三叉血管系统中相互促进彼此的释放，可能促进偏头痛的发展。由于二氨基氧化酶（DAO）基因突变而导致组胺降解缺陷的患者，高组胺含量的饮食会引发偏头痛。因此，研究外源性组胺和 CGRP 之间的功能联系似乎有利于了解饮食引起的偏头痛的发生。值得注意的是，人们对肠神经系统和脊髓/三叉神经体感系统与 CGRP 和组胺之间的相互作用缺乏了解。基于背景证据，我们提出外源性组胺和 CGRP 之间的功能互连有助于偏头痛的发生。