Despite successes with new drug approvals over the past two decades through conventional drug development approaches, many human diseases remain intractable to current therapeutic interventions. Possible barriers may be that the complexity of the target, and disease biology, are impervious to such conventional drug development approaches. The US National Institutes of Health hosted a workshop with the goal of identifying challenges and opportunities with alternative modalities for developing treatments across diseases associated with historically undruggable targets. This report highlights key issues discussed during the workshop that, if addressed, could expand the pool of therapeutic approaches for treating various diseases.

中文翻译：

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挑战治疗目标的新方法

尽管在过去二十年中通过传统药物开发方法取得了新药批准的成功，但许多人类疾病仍然难以通过当前的治疗干预措施来解决。可能的障碍可能是靶点和疾病生物学的复杂性不受这种传统药物开发方法的影响。美国国立卫生研究院主办了一次研讨会，目的是确定替代模式的挑战和机遇，以开发与历史上不可成药目标相关的疾病的治疗方法。本报告强调了研讨会期间讨论的关键问题，如果解决这些问题，可以扩大治疗各种疾病的治疗方法。