Objective

To determine associations of maternal salivary aldosterone with blood pressure (BP) in pregnancy and infant birth weight-for-gestational age (BWGA).

Methods

We measured maternal salivary aldosterone, BP and BWGA z-scores in 471 Mexico City pregnancy cohort participants and performed multivariable linear regression of BP and BWGA on log-aldosterone levels.

Results

Log-aldosterone was positively associated with diastolic BP (β = 0.12 95% CI: 0.04, 0.21). There were no main effects of log-aldosterone on BWGA. However, we detected an interaction between log-aldosterone and BP in association with BWGA; higher log-aldosterone was associated with lower BWGA in the lowest (β = −0.12, 95% CI: -0.26, 0.02) and highest (β = −0.12, 95% CI: −0.29, 0.06) BP tertiles. In contrast, in the middle BP tertile the association was positive (β = 0.09, 95% CI: −0.02, 0.20), p for interaction = 0.03.

Conclusion

Higher maternal salivary aldosterone is positively associated with diastolic BP and may affect fetal growth differently depending on concurrent maternal blood pressure.

中文翻译：

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墨西哥城出生队列中妊娠期唾液醛固酮水平与母亲血压和出生胎龄体重的关联

客观的

确定母亲唾液醛固酮与妊娠期血压 (BP) 和婴儿出生胎龄体重 (BWGA) 的关系。

方法

我们测量了 471 名墨西哥城妊娠队列参与者的母亲唾液醛固酮、血压和 BWGA z 分数，并对醛固酮水平的对数进行了血压和 BWGA 的多变量线性回归。

结果

对数醛固酮与舒张压呈正相关（β  = 0.12 95% CI：0.04，0.21）。对数醛固酮对 BWGA 没有主要影响。然而，我们检测到对数醛固酮和 BP 之间存在与 BWGA 相关的相互作用；在最低（β  = -0.12，95% CI：-0.26，0.02）和最高（β = -0.12，95% CI：-0.29，0.06）BP三分位中，较高的对数醛固酮与较低的BWGA相关。相反，在中间血压三分位数中，相关性为正相关（β = 0.09，95% CI：-0.02，0.20），交互作用p = 0.03。

结论

较高的母亲唾液醛固酮与舒张压呈正相关，并且可能对胎儿生长产生不同的影响，具体取决于同时发生的母亲血压。