A simple and efficient method has been developed for the synthesis of a diverse range of aryl-fused indolizin-3-ones through sequential Au(I)-catalyzed hydrocarboxylation, aminolysis, and cyclization, followed by ruthenium-catalyzed ring-closing metathesis. Moderate to good yields were observed with satisfactory substrate scope and functional group tolerance. The developed protocol represents a practical strategy for the construction of bioactive aryl-fused indolizin-3-ones.

中文翻译：

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通过“一锅法”顺序接力催化从 α,ω-炔酸和 α,ω-乙烯基胺构建中氮茚支架

我们开发了一种简单有效的方法，通过连续的 Au( I ) 催化的加氢羧化、氨解和环化，然后进行钌催化的闭环复分解来合成各种芳基稠合吲哚嗪-3-酮。观察到中等至良好的产率，具有令人满意的底物范围和官能团耐受性。所开发的方案代表了构建生物活性芳基融合吲哚嗪-3-酮的实用策略。