Autism Spectrum Disorder (ASD) is a neurodevelopmental disturbance, diagnosed in early childhood. It is associated with varying degrees of dysfunctional communication and social skills, repetitive and stereotypic behaviors. Regardless of the constant increase in the number of diagnosed patients, there are still no established treatment schemes in global practice. Many children with ASD have allergic symptoms, often in the absence of mast cell (MC) positive tests. Activation of MCs may release molecules related to inflammation and neurotoxicity, which contribute to the pathogenesis of ASD. The aim of the present paper is to enrich the current knowledge regarding the relationship between MCs and ASD by providing PPI network analysis-based data that reveal key molecules and immune pathways associated with MCs in the pathogenesis of autism. Network and enrichment analyzes were performed using receptor information and secreted molecules from activated MCs identified in ASD patients. Our analyses revealed cytokines and key marker molecules for MCs degranulation, molecular pathways of key mediators released during cell degranulation, as well as various receptors. Understanding the relationship between ASD and the activation of MCs, as well as the involved molecules and interactions, is important for elucidating the pathogenesis of ASD and developing effective future treatments for autistic patients by discovering new therapeutic target molecules.

中文翻译：

---

肥大细胞 - 自闭症谱系障碍中的细胞因子轴

自闭症谱系障碍 (ASD) 是一种神经发育障碍，在儿童早期被诊断出来。它与不同程度的沟通和社交技能功能失调、重复和刻板行为有关。尽管确诊患者数量不断增加，但全球实践中仍然没有既定的治疗方案。许多患有自闭症谱系障碍 (ASD) 的儿童都会出现过敏症状，而且通常没有肥大细胞 (MC) 检测呈阳性。 MC 的激活可能会释放与炎症和神经毒性相关的分子，从而促进 ASD 的发病机制。本文的目的是通过提供基于 PPI 网络分析的数据来丰富当前关于 MC 和 ASD 之间关系的知识，这些数据揭示了自闭症发病机制中与 MC 相关的关键分子和免疫途径。使用 ASD 患者中识别的激活 MC 的受体信息和分泌分子进行网络和富集分析。我们的分析揭示了 MC 脱颗粒的细胞因子和关键标记分子、细胞脱颗粒过程中释放的关键介质的分子途径以及各种受体。了解 ASD 与 MC 激活之间的关系，以及所涉及的分子和相互作用，对于阐明 ASD 的发病机制以及通过发现新的治疗靶分子为自闭症患者开发有效的未来治疗方法具有重要意义。