Pruritus or itch is a defining symptom of atopic dermatitis (AD). The origins of itch are complex, and it is considered both a defense mechanism and a cause of disease that leads to inflammation and psychological stress. Considerable progress has been made in understanding the processes that trigger itch, particularly the pruritoceptive origins that are generated in the skin. This perspective review discusses the implications of a recent observation that the V8 protease expressed by can directly trigger sensory neurons in the skin through activation of protease-activated receptor 1. This may be a key to understanding why itch is so common in AD because commonly overgrows in this disease owing to deficient antimicrobial defense from both the epidermis and the cutaneous microbiome. Increased understanding of the role of microbes in AD provides increased opportunities for safely improving the treatment of this disorder.

中文翻译：

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金黄色葡萄球菌：特应性皮炎瘙痒背后的细菌

瘙痒或瘙痒是特应性皮炎 (AD) 的典型症状。瘙痒的起源很复杂，它被认为既是一种防御机制，也是导致炎症和心理压力的疾病原因。在了解引发瘙痒的过程，特别是皮肤中产生的瘙痒感受起源方面，已经取得了相当大的进展。这篇透视综述讨论了最近观察到的结果的意义，即 表达的 V8 蛋白酶可以通过激活蛋白酶激活受体 1 直接触发皮肤中的感觉神经元。这可能是理解为什么瘙痒在 AD 中如此常见的关键，因为通常会过度生长。在这种疾病中，由于表皮和皮肤微生物组的抗菌防御不足。对微生物在 AD 中的作用的更多了解为安全地改善这种疾病的治疗提供了更多机会。