Environment–epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms outside of the laboratory are constantly exposed to environmental changes that can influence chromatin regulation at multiple levels, potentially impacting on genome function. In this review, we will summarize recent findings on how major external cues impact on 3D chromatin organization in different experimental systems. We will describe environment-induced 3D genome alterations ranging from chromatin accessibility to the spatial distribution of the genome and discuss their role in regulating gene expression.

中文翻译：

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影响者时代：环境如何以 3D 方式塑造染色质

环境与表观基因组的相互作用正在成为疾病风险和健康结果的影响因素。事实上，实验室外的生物体不断暴露于环境变化，这些变化可能会在多个层面上影响染色质调控，从而可能影响基因组功能。在这篇综述中，我们将总结关于主要外部线索如何影响不同实验系统中 3D 染色质组织的最新发现。我们将描述环境诱导的 3D 基因组改变（从染色质可及性到基因组的空间分布），并讨论它们在调节基因表达中的作用。