Mitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in , used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and transport. Their work sheds light on the development of gastrointestinal disorders as a result of mitochondrial dysfunction.

中文翻译：

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脂质加工和胃肠道疾病中的线粒体功能障碍

线粒体功能障碍主要引起伴有肌肉萎缩和神经变性的脑肌病。然而，它们对其他组织，特别是胃肠道的影响需要进一步研究。在最近的一份报告中，使用线粒体氨酰基-tRNA 合成酶 DARS2 缺陷的小鼠来研究肠细胞线粒体在饮食脂质加工和运输中的作用。他们的工作揭示了线粒体功能障碍导致胃肠道疾病的发展。