Previous studies reported that sleeping disorders were associated with presence and severity of coronary artery disease (CAD). We aimed to evaluate the relationship between the angiographic progression of CAD with sleep quality. We enrolled 690 patients who had angiography history with diagnosis of chronic CAD, requiring new angiography according to clinical, and laboratory evaluation among 1654 patients with complaint of stable angina. Previous and new coronary angiography images of patients were compared to evaluate the presence of angiographic progression using quantitative coronary analysis measurement. A 1:2 propensity score matching was performed. Thus, the patient population was divided into two groups including non-progressors group (n = 156) and progressors group (n = 78). Groups were compared in terms of sleep quality and disorder using Pittsburgh Sleep Quality Index (PSQI) and STOP-Bang questionnaire. Progressors had shorter sleep duration, higher PSQI score indicating poorer sleep quality and higher STOP BANG score indicating increased sleep apnea risk than non-progressors (p < 0.05). The multivariate logistic regression analysis determined that night shift work (OR: 1.38, p = 0.04), sleep duration difference (OR: 1.25, p = 0.03), poorer sleep quality (OR: 2.08, p = 0.01), high STOP BANG score (OR: 1.86, p = 0.004), and high risk of sleep apnea (OR: 3.84, p = 0.008) were independently associated with significant risk of angiographic CAD progression. Our findings suggested that angiographically proven chronic CAD progression was associated with poor sleep quality including high apnea risk. Selected patients should be subjected to an advanced evaluation including sleep study to diagnose sleep disorders such as sleep apnea. Treatment of sleep disorders can support existing medical and/or invasive treatments in chronic CAD and improve outcomes.

中文翻译：

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一项观察性研究：慢性冠状动脉疾病患者睡眠质量与血管造影进展之间的关系

先前的研究报告称，睡眠障碍与冠状动脉疾病（CAD）的存在及其严重程度有关。我们的目的是评估 CAD 血管造影进展与睡眠质量之间的关系。我们在 1654 名主诉稳定型心绞痛的患者中纳入了 690 名有血管造影史并诊断为慢性 CAD 的患者，根据临床和实验室评估需要进行新的血管造影。比较患者之前和新的冠状动脉造影图像，以使用定量冠状动脉分析测量来评估血管造影进展的存在。进行了 1:2 倾向评分匹配。因此，患者群体被分为两组，包括非进展组（n = 156）和进展组（n = 78）。使用匹兹堡睡眠质量指数 (PSQI) 和 STOP-Bang 问卷对各组的睡眠质量和障碍进行比较。与非进展者相比，进展者睡眠时间较短，PSQI 评分较高，表明睡眠质量较差；STOP BANG 评分较高，表明睡眠呼吸暂停风险增加 (p < 0.05)。多变量逻辑回归分析确定夜班工作（OR：1.38，p = 0.04）、睡眠时间差异（OR：1.25，p = 0.03）、睡眠质量较差（OR：2.08，p = 0.01）、高STOP BANG评分（OR：1.86，p = 0.004）和睡眠呼吸暂停高风险（OR：3.84，p = 0.008）与血管造影 CAD 进展的显着风险独立相关。我们的研究结果表明，经血管造影证明慢性 CAD 进展与睡眠质量差（包括高呼吸暂停风险）有关。选定的患者应接受高级评估，包括睡眠研究，以诊断睡眠呼吸暂停等睡眠障碍。睡眠障碍的治疗可以支持慢性 CAD 的现有药物和/或侵入性治疗并改善治疗结果。