Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.

中文翻译：

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用于生物制造和农业的基于过氧化物酶体的代谢工程

代谢途径的亚细胞区室化在代谢工程中起着至关重要的作用。过氧化物酶体已成为细胞器工程中非常有价值和有前途的隔室，特别是在生物制造和农业领域。在这篇综述中，我们总结了工业上流行的生物制造底盘宿主酵母过氧化物酶体工程在生产各种生物化合物方面取得的显着成就。我们还回顾了植物过氧化物酶体工程的进展，该领域已经在生物制造和农业方面展现出巨大的潜力。此外，我们概述了各种经过实验验证的策略，以提高过氧化物酶体工程途径的效率，以及过氧化物酶体工程的前景。