Implantable medical devices have played an important role in human medicine in recent decades. However, traditional implanted devices require battery replacement and a second surgery for device removal, which can cause pain to the patient. This work presents a biodegradable triboelectric nanogenerator (BI-TENG) made from both natural and synthetic biodegradable materials that is utilized to collect mechanical energy in vivo and transduce it into electricity. Reed film and polylactic acid were chosen among different biodegradable materials as the triboelectric layers due to having the best generator output performance by providing voltages that reached 368 V. The biocompatibility of the friction layer and the device was verified via a blood test. After implantation in mice, the BI-TENG exhibited an open-circuit voltage of 0.176 V and a short-circuit current of 192 nA as generated from body movement. The BI-TENG was connected to an interdigital electrode to generate an electric field, which stimulated the accelerated release of doxorubicin (DOX) from red blood cells in targeted drug delivery systems. After stopping the electric field, the release of DOX normalized, facilitating the precise killing of cancer cells. Our work demonstrates the broad potential of BI-TENGs in the field of cancer treatment.

近几十年来，植入式医疗器械在人类医学中发挥了重要作用。然而，传统的植入设备需要更换电池并进行第二次手术以移除设备，这可能会给患者带来痛苦。这项工作提出了一种由天然和合成可生物降解材料制成的可生物降解摩擦纳米发电机（BI-TENG），用于收集体内机械能并将其转化为电能。在不同的可生物降解材料中选择簧片和聚乳酸作为摩擦电层，因为它们具有最佳的发电机输出性能，可提供高达 368 V 的电压。通过血液测试验证了摩擦层和设备的生物相容性。植入小鼠体内后，BI-TENG 因身体运动而产生的开路电压为 0.176 V，短路电流为 192 nA。BI-TENG 连接到叉指电极以产生电场，刺激靶向药物输送系统中的红细胞加速释放阿霉素 (DOX)。停止电场后，DOX 的释放恢复正常，有利于精确杀死癌细胞。我们的工作展示了 BI-TENG 在癌症治疗领域的广泛潜力。