Chemical investigation of Hook. f. led to the isolation of four undescribed rearranged diterpenoids, euphwanoids I-IV (-), and six unreported tigliane diterpenoids walliglianes A-F (–). Euphwanoids I-III (–) possess a rare 6/6/7/3 ring scaffold, euphwanoid IV () is the first spiro[tricyclo[5.4.0.0]undecane-8,1ʹ-cyclopentane] skeleton to be found in the tigliane family. The structures of compounds – were established by utilizing spectroscopic data analysis, experimental electronic circular dichroism measurements, C NMR calculations, and single-crystal X-ray diffraction. In the preliminary bioassay, compounds 3, 4, and 7 were found to protect BV-2 cells against HO-induced cell injury in a dose-dependent manner by the CCK8 assay.

中文翻译：

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来自大戟的结构有趣的二萜类化合物。 F。具有潜在的抗氧化活性

胡克的化学调查。 F。导致分离出四种未描述的重排二萜类化合物 euphwanoids I-IV (-) 和六种未报道的 tigliane 二萜类化合物 walliglianes AF (-)。 Euphwanoids I-III (–) 拥有罕见的 6/6/7/3 环支架，euphwanoid IV () 是在 tigliane 中发现的第一个螺[三环[5.4.0.0]十一烷-8,1ʹ-环戊烷]骨架家庭。化合物的结构——通过利用光谱数据分析、实验电子圆二色性测量、13C NMR 计算和单晶 X 射线衍射来确定。在初步生物测定中，CCK8 测定发现化合物 3、4 和 7 以剂量依赖性方式保护 BV-2 细胞免受 H2O2 诱导的细胞损伤。