Background and objective

Hospitalized preterm infants experience reduced meaningful auditory exposures during a critical period of brain development. Music-based interventions (MBI) may be beneficial, though it remains unclear which stimuli optimally enhance infant stabilization. We investigated the relationship between three conceptually-different MBIs and short-term responses in hospitalized preterm infants.

Study design

This is a case-crossover pilot study including 21 preterm infants between 30 and 35 weeks postmenstrual age. Participants listened to three MBIs and ‘no music’; each condition was provided three times in random order. We monitored physiologic and behavioral parameters around each exposure and analyzed results using linear mixed models.

Results

Respiratory rates decreased after each MBI compared with ‘no music’ (p = 0.02). The most notable decrease occurred following exposure to a low, repetitive musical pattern resembling a lullaby (p = 0.01). We noted no significant changes for the remaining parameters.

Conclusion

Specific MBI characteristics may preferentially enhance physiologic stabilization in hospitalized preterm infants.

中文翻译：

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基于音乐的干预对住院早产儿生理稳定性的影响。试点研究

背景和目标

在大脑发育的关键时期，住院的早产儿经历的有意义的听觉暴露减少。基于音乐的干预（MBI）可能是有益的，但目前尚不清楚哪种刺激最能增强婴儿的稳定性。我们研究了三种概念上不同的 MBI 与住院早产儿短期反应之间的关系。

学习规划

这是一项病例交叉试点研究，纳入了 21 名月经后 30 至 35 周的早产儿。参与者听了三首 MBI，但“没有音乐”；每个条件以随机顺序提供三次。我们监测每次暴露的生理和行为参数，并使用线性混合模型分析结果。

结果

与“不听音乐”相比，每次 MBI 后呼吸频率下降（p  = 0.02）。最显着的下降发生在接触类似摇篮曲的低沉、重复的音乐模式后（p  = 0.01）。我们注意到其余参数没有显着变化。

结论

特定的 MBI 特征可能会优先增强住院早产儿的生理稳定性。