Small cell lung carcinoma (SCLC) cell lines have been widely utilized as a preclinical model of this highly aggressive disease. However, since their creation decades ago, novel tumor entities have been defined that may clinicopathologically mimic SCLC, which notably includes thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT). Multi-omic reassessment of the presumed SCLC cell lines with high YAP1 expression reveals that nearly all of these tumors represent unsuspected SMARCA4-UT.

中文翻译：

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所有小的都不是小细胞癌：伪装成 SCLC 的胸部 SMARCA4 未分化肿瘤

小细胞肺癌（SCLC）细胞系已被广泛用作这种高度侵袭性疾病的临床前模型。然而，自几十年前诞生以来，已经定义了可能在临床病理学上模仿 SCLC 的新肿瘤实体，其中特别包括胸部 SMARCA4 缺陷型未分化肿瘤（SMARCA4-UT）。对假定的具有高 YAP1 表达的 SCLC 细胞系的多组学重新评估表明，几乎所有这些肿瘤都代表了未被怀疑的 SMARCA4-UT。