Cholinium α-amino carboxylates, which debuted in the ionic liquid arena over a decade ago, exhibit superior stability and suitable physical properties relative to other RTILs. Although synthetic pursuits in such media, leveraging their dual role as solvents and catalysts, have been scarce so far, we herein illustrate their catalytic advantage in aza-Michael reactions in terms of low loading, acceleration and improved yields with respect to conventional conditions and other imidazolium-based ILs. These highly structured salts most likely act through multiple and cooperative non-covalent interactions. These mechanistic features have also been investigated through high-level computational analyses as well.

中文翻译：

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在离子液体催化下重振氮杂迈克尔反应：更环保的方法

α-氨基羧酸胆碱盐十多年前首次出现在离子液体领域，相对于其他 RTIL 表现出优异的稳定性和合适的物理性质。尽管迄今为止在此类介质中利用其作为溶剂和催化剂的双重作用的合成研究还很少，但我们在此说明了它们在氮杂迈克尔反应中相对于常规条件和其他条件的低负载、加速和提高产率方面的催化优势。基于咪唑的离子液体。这些高度结构化的盐很可能通过多种协作的非共价相互作用起作用。这些机械特征也通过高级计算分析进行了研究。