Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated to atrophied regions in frontotemporal dementia. Here, we aim to determine whether increased thickness occurs in sporadic AD, whether it relates to clinical symptoms, and whether it occur in brain regions functionally connected to—but anticorrelated with—locations of atrophy.

中文翻译：

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阿尔茨海默氏病的皮质厚度增加

阿尔茨海默病（AD）患者患有弥漫性脑萎缩，但某些区域，例如前扣带皮层（ACC），却没有受到影响，甚至与对照组相比，脑部体积有所增加。AD 中皮质厚度增加的程度、临床意义和机制仍不清楚。最近的研究表明，额颞叶痴呆中与萎缩区域反相关的区域的神经促进作用。在这里，我们的目的是确定厚度增加是否发生在散发性 AD 中，它是否与临床症状相关，以及它是否发生在与萎缩位置功能相关但不相关的大脑区域。