Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501,Annals of Neurology

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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501
Annals of Neurology ( IF 11.2 ) Pub Date : 2024-02-24 , DOI: 10.1002/ana.26899
Yaqing Shu ₁ , Renliang Huang ₂ , Qihui Li ₁ , Yi Lu ₃ , Junping Yin ₄ , Huilu Li ₁ , Zhike Lan ₅ , Xiujun Zheng ₆ , Jinlong Ye ₅ , Youming Long ₇ , Zhanhang Wang ₅ , Li Xiao ₁ , Qiaomiao Zhou ₂ , Xu Liu ₈ , Ying Fu ₉ , Hao Chen ₁₀ , Juanjuan Chen ₁₁ , Yanxia Zhou ₁₂ , Juan Zhou ₁₃ , Liting Zhang ₁₄ , Jing Zhou ₁₅ , Ying Jiang ₁ , Fuhua Peng ₁ , Zhengqi Lu ₁ , Frank Petersen ₁₆ , Wei Qiu ₁ , Xinhua Yu _{2,

16}

Affiliation

Department of Neurology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou China
Department of Genetics and Prenatal Diagnosis Hainan Women and Children's Medical Center Haikou Hainan China
Department of Neurology, The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen China
Institute of Molecular Medicine and Experimental Immunology, University of Bonn Bonn Germany
Department of Neurology GuangDong 999 Brain Hospital Guangzhou China
Department of Neurology Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat‐Sen University Shantou China
Department of Neurology, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University Guangzhou China
Department of Neurology, West China Hospital Sichuan University Chengdu China
Department of Neurology and Institute of Neurology The First Affiliated Hospital of Fujian Medical University Fuzhou China
Department of Neurology The First Affiliated Hospital Nanchang University Nanchang China
Department of Neurology Peking University Shenzhen Hospital Shenzhen China
Department of Neurology Shenzhen Second Peopleʼs Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center Shenzhen China
Department of Neurology Chenzhou First People's Hospital Chenzhou China
Department of Neurology Jiangxi Chest Hospital Jiangxi China
Department of Neurology Foshan First People's Hospital Foshan China
Division of Pulmonary Immune Diseases Priority Area Chronic Lung Diseases, Research Center Borstel Borstel Germany

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32–3.06, p = 0.00072, padj. = 0.046) and HLA‐DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA‐A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non‐carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024

中文翻译：

自身免疫性胶质纤维酸性蛋白星形细胞病与 HLA-A*3303 和 HLA-DPB1*0501 相关

我们确定了特定人类白细胞抗原（HLA）基因座与自身免疫性胶质纤维酸性蛋白（GFAP）星形细胞病之间的遗传关联。我们的结果表明，自身免疫性 GFAP 星形细胞病与 HLA-A*3303 相关（比值比 [OR] = 2.02，95% 置信区间 [CI] = 1.32–3.06，p= 0.00072,p形容词= 0.046) 和 HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71,p= 0.000048,p形容词= 0.0062)。此外，患有该疾病的 HLA-A*3303 携带者住院时间较长（p= 0.0005）比非载体。这项研究首次为遗传因素在自身免疫性 GFAP 星形细胞病的发展中的作用提供了证据。安神经学 2024

更新日期：2024-02-24

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