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Small Molecule-Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs
ChemMedChem ( IF 3.4 ) Pub Date : 2024-02-23 , DOI: 10.1002/cmdc.202300720
Jingjing Zhang 1 , Fanchun Hu 1 , Omer Aras 2 , Yichao Chai 3 , Feifei An 4
Affiliation  

Consisting of three parts: targeting ligand, cleavable linker and payload, small molecule drug conjugates (SMDCs) are a promising class of targeted drugs. Giving the advantages of smaller size, better permeability, simpler preparation process and non-immunogenicity, SMDCs might be a promising alternative to antibody drug conjugates (ADCs).

中文翻译:

小分子药物偶联物:靶向抗癌药物开发的机遇

小分子药物偶联物(SMDC)由靶向配体、可裂解连接体和有效负载三部分组成,是一类有前途的靶向药物。SMDC 具有尺寸更小、渗透性更好、制备过程更简单和非免疫原性等优点,可能成为抗体药物偶联物 (ADC) 的有前途的替代品。
更新日期:2024-02-23
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