A mathematical model of a spiking neuron network accompanied by astrocytes is considered. The network is composed of excitatory and inhibitory neurons with synaptic connections supplied by a memristor-based model of plasticity. Another mechanism for changing the synaptic connections involves astrocytic regulations using the concept of tripartite synapses. In the absence of memristor-based plasticity, the connections between these neurons drive the network dynamics into a burst mode, as observed in many experimental neurobiological studies when investigating living networks in neuronal cultures. The memristive plasticity implementing synaptic plasticity in inhibitory synapses results in a shift in network dynamics toward an asynchronous mode. Next,it is found that accounting for astrocytic regulation in glutamatergic excitatory synapses enable the restoration of ‘normal’ burst dynamics. The conditions and parameters of such astrocytic regulation’s impact on burst dynamics established.

中文翻译：

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星形胶质细胞控制具有忆阻器实现可塑性的尖峰神经元网络的爆发模式

考虑了星形胶质细胞伴随的尖峰神经元网络的数学模型。该网络由兴奋性和抑制性神经元组成，其突触连接由基于忆阻器的可塑性模型提供。改变突触连接的另一种机制涉及使用三方突触概念的星形胶质细胞调节。在缺乏基于忆阻器的可塑性的情况下，这些神经元之间的连接将网络动态驱动到突发模式，正如许多实验神经生物学研究在研究神经元培养物中的活网络时所观察到的那样。在抑制性突触中实现突触可塑性的忆阻可塑性导致网络动态向异步模式转变。接下来，发现考虑谷氨酸能兴奋性突触中的星形胶质细胞调节能够恢复“正常”爆发动力学。这种星形胶质细胞调节对爆发动力学影响的条件和参数已确定。