Cell death plays a crucial part in the process of age-related macular degeneration (AMD), but its mechanisms remain elusive. Accumulating evidence suggests that ferroptosis, a novel form of regulatory cell death characterized by iron-dependent accumulation of lipid hydroperoxides, has a crucial role in the pathogenesis of AMD. Numerous studies have suggested that ferroptosis participates in the degradation of retinal cells and accelerates the progression of AMD. Furthermore, inhibitors of ferroptosis exhibit notable protective effects in AMD, underscoring the significance of ferroptosis as a pivotal mechanism in the death of retinal cells during the process of AMD. This review aims to summarize the molecular mechanisms of ferroptosis in AMD, enumerate potential inhibitors and discuss the challenges and future opportunities associated with targeting ferroptosis as a therapeutic strategy, providing important information references and insights for the prevention and treatment of AMD.

中文翻译：

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铁死亡作为年龄相关性黄斑变性的潜在治疗靶点

细胞死亡在年龄相关性黄斑变性（AMD）的过程中起着至关重要的作用，但其机制仍然难以捉摸。越来越多的证据表明，铁死亡是一种新型的调节性细胞死亡形式，其特征是铁依赖性脂质氢过氧化物的积累，在 AMD 的发病机制中起着至关重要的作用。大量研究表明铁死亡参与视网膜细胞的降解并加速AMD的进展。此外，铁死亡抑制剂在AMD中表现出显着的保护作用，强调了铁死亡作为AMD过程中视网膜细胞死亡的关键机制的重要性。本文旨在总结AMD铁死亡的分子机制，列举潜在的抑制剂，并讨论铁死亡作为治疗策略的挑战和未来机遇，为AMD的预防和治疗提供重要的信息参考和见解。