The phosphate ester monomer 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) is capable of bonding to hydroxyapatite and, for this reason, is a key component of several self-etch adhesives. In this study, dicalcium phosphate dihydrate particles (DCPD; CaHPO4.2H2O) were functionalized with 10-MDP and used to formulate an experimental composite with 50 vol% inorganic content (3:1 DCPD:silanated barium glass ratio) dispersed in a BisGMA/TEGDMA matrix. The tested hypothesis was that DCPD functionalization would improve the composite’s mechanical performance without compromising Ca2+ release. Composites containing nonfunctionalized DCPD or only reinforcing glass (in both cases, with or without 10-MDP mixed in the resin phase) were used as controls. Materials were tested for degree of conversion (DC; by Fourier transform infrared spectroscopy), water sorption (WS) and solubility (SL; according to ISO 4049), biaxial flexural strength (BFS)/modulus (FM) after 24 h and 5 mo in water, and 28-d Ca2+ release in water (by plasma-coupled optical emission spectroscopy). Data were analyzed using analysis of variance/Tukey test (alpha: 5%). DCPD functionalization did not interfere with DC. The composite containing functionalized DCPD showed significantly lower WS and SL in comparison with the material formulated with nonfunctionalized particles. The presence of 10-MDP (as a functionalizing agent or dispersed in the resin phase) reduced the composite’s initial BFS and FM. After 5 mo in water, the composite with functionalized DCPD and both glass-only composites were able to maintain their mechanical properties at levels statistically similar to what was observed after 24 h. Ca2+ release was significantly reduced in both formulations containing 10-MDP. In conclusion, DCPD functionalization with 10-MDP increased the composite’s resistance to hydrolytic degradation, improving its mechanical stability after prolonged water storage. However, the impaired water transit at the particle-matrix interface led to a reduction in Ca2+ release.

中文翻译：

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含有 10-MDP 功能化磷酸钙颗粒的复合材料

磷酸酯单体 10-甲基丙烯酰氧基癸基磷酸二氢酯 (10-MDP) 能够粘合羟基磷灰石，因此是多种自蚀刻粘合剂的关键成分。在这项研究中，二水磷酸二钙颗粒（DCPD；CaHPO4.2小时2O) 用 10-MDP 进行功能化，并用于配制分散在 BisGMA/TEGDMA 基质中的 50 vol% 无机含量（3:1 DCPD: 硅烷化钡玻璃比例）的实验复合材料。测试的假设是 DCPD 功能化将提高复合材料的机械性能而不影响 Ca2+发布。含有非官能化 DCPD 或仅含有增强玻璃的复合材料（在这两种情况下，在树脂相中混合或不混合 10-MDP）用作对照。测试材料的转化度（DC；通过傅里叶变换红外光谱）、吸水性（WS）和溶解度（SL；根据 ISO 4049）、24 小时和 5 个月后的双轴弯曲强度 (BFS)/模量 (FM)水中和 28-d Ca2+释放到水中（通过等离子体耦合发射光谱法）。使用方差分析/Tukey 检验（α：5%）对数据进行分析。DCPD功能化不干扰DC。与用非官能化颗粒配制的材料相比，含有官能化 DCPD 的复合材料显示出显着较低的 WS 和 SL。10-MDP（作为功能化剂或分散在树脂相中）的存在降低了复合材料的初始 BFS 和 FM。在水中放置 5 个月后，具有官能化 DCPD 的复合材料和两种纯玻璃复合材料能够将其机械性能保持在与 24 小时后观察到的统计水平相似的水平。钙2+两种含有 10-MDP 的制剂的释放均显着减少。总之，用 10-MDP 进行 DCPD 功能化提高了复合材料的耐水解降解性，提高了其在长期水储存后的机械稳定性。然而，颗粒-基体界面处的水传输受损导致 Ca 减少2+发布。