To evaluate and compare the biometric characteristics of the anterior chamber of a group of patients with significant endothelial cell loss (ECL) that required phakic IOL (pIOL) explantation and a group of patients who did not fulfill the explantation criteria related to corneal decompensation. Retrospective consecutive interventional case series The study included all consecutive patients implanted with pIOL at , Lima, Peru, between 2001 and 2012. The explanted group (E-group) consisted of eyes in which the pIOLs were explanted due to ECL and the non-explanted group (NE-group) consisted of eyes randomly selected in which the pIOL was not explanted with a minimum follow-up time of eight years. Slit-lamp biomicroscopy, visual acuity, refraction, endothelial cells count, and anterior segment OCT were assessed at the preoperative evaluation for both groups and before explantation in the E-group and eight years post implantation in the NE-group. 265 eyes were implanted with pIOL. The annual percentage of ECL was 1.47% and 5.55% in the NE-group and the E-group, respectively ( < .001). The mean minimum endothelial lens distance (min-ELD) was 1.44 ± 0.22 mm and 1.05 ± 0.23 mm in the NE-group and the E-group, respectively ( < 0.001). The mean time for explantation was 12.58 ± 3.79 years for the NE-group. Annual ECL could accurately discriminate between NE-group and E-group, a cutoff point of 3.5 (%/year) or 86.5 (cells/years) had a 100% sensitivity and specificity. A cutoff of 1.21 mm in the min-ELD, has a 91% sensitivity and 79% specificity to discriminate between E-group and NE-group. pIOL explantation due to ECL occurs in eyes with a significantly postoperative lower min-ELD. Annual ECL and min-ELC can effectively discriminate between explanted and non-explanted groups.

中文翻译：

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虹膜固定有晶状体眼人工晶状体长期植入外植眼与非外植眼的生物特征比较

评估和比较一组患有显着内皮细胞丢失（ECL）且需要有晶体眼人工晶状体（pIOL）移植的患者和一组不符合角膜失代偿相关移植标准的患者的前房生物特征。回顾性连续介入病例系列 该研究包括 2001 年至 2012 年间在秘鲁利马植入 pIOL 的所有连续患者。 外植组（E 组）包括因 ECL 而外植 pIOL 的眼睛和未外植的眼睛。组（NE组）由随机选择的眼睛组成，其中未移植pIOL，最短随访时间为八年。对两组患者的术前评估、E 组移植前和 NE 组移植后八年进行裂隙灯生物显微镜检查、视力、屈光、内皮细胞计数和眼前段 OCT 评估。265只眼睛植入了pIOL。NE 组和 E 组的年 ECL 百分比分别为 1.47% 和 5.55% ( < .001)。NE组和E组的平均最小内皮晶状体距离（min-ELD）分别为1.44±0.22mm和1.05±0.23mm（<0.001）。NE 组的平均移植时间为 12.58 ± 3.79 年。年度ECL可以准确地区分NE组和E组，截止点为3.5（％/年）或86.5（细胞/年），具有100％的敏感性和特异性。min-ELD 的截止值为 1.21 mm，区分 E 组和 NE 组的灵敏度为 91%，特异性为 79%。由于 ECL 导致的 pIOL 移出发生在术后 min-ELD 显着降低的眼睛中。每年的 ECL 和 min-ELC 可以有效区分外植组和非外植组。