Mechanical forces are ubiquitously present in biology. In recent years, it has become clear how plasma membranes detect these forces — but how do intracellular organelles such as lysosomes do the same, and what might be the functions of such intracellular mechanosensing? Answers may come through a report of a lysosomal mechanosensitive ion channel, TMEM63.

中文翻译：

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溶酶体通道感知力

机械力在生物学中无处不在。近年来，人们已经清楚质膜如何检测这些力，但是溶酶体等细胞内细胞器如何做同样的事情，这种细胞内机械传感的功能可能是什么？溶酶体机械敏感离子通道 TMEM63 的报告可能会给出答案。