Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates,Journal of Perinatology

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Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
Journal of Perinatology ( IF 2.9 ) Pub Date : 2024-02-23 , DOI: 10.1038/s41372-024-01905-7
Sanjay Chawla , Abbot R. Laptook , Emily A. Smith , Sylvia Tan , Girija Natarajan , Myra H. Wyckoff , Rachel G. Greenberg , Namasivayam Ambalavanan , Edward F. Bell , Krisa P. Van Meurs , Susan R. Hintz , Betty R. Vohr , Erika F. Werner , Abhik Das , Seetha Shankaran , Waldemar A. Carlo , Anna Maria Hibbs , Stephanie Merhar , C. Michael Cotten , Ravi M. Patel , Tarah T. Colaizy , Aaron Hamvas , Abhay J. Bhatt , Janell Fuller , Sara DeMauro , Anup C. Katheria , Robin K. Ohls , Jon E. Tyson ,

Objective

To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI).

Methods

This retrospective cohort study included extremely preterm infants (gestational age 22^0/7–26^6/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.

Results

Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models.

Conclusion

Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

中文翻译：

母亲孕前或孕早期体重指数与极低胎龄新生儿神经发育障碍或死亡的关系

客观的

比较极早产儿 2 岁时患有严重神经发育障碍 (sNDI) 的死亡率或生存率与孕前或孕早期母亲体重指数 (BMI) 的关系。

方法

这项回顾性队列研究包括极早产儿（胎龄 22 ^0/7 –26 ^6/7周）。该研究是在国家儿童健康和人类发展研究所新生儿研究网络站点进行的。主要结局是 2 岁时死亡或 sNDI。

结果

可获得 1208 名儿童的主要结局数据。三组之间的死亡或 sNDI 没有差异：正常组为 54.9%，超重组为 56.1%，肥胖组为 53.4% ( p = 0.39)。调整后的模型中，死亡率、sNDI、中/重度脑瘫、贝利婴儿发育量表（BSID）-III认知综合评分<70、BSID-III语言综合评分<70无显着差异。