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Staphylococcus haemolyticus: An updated review on nosocomial infections, antimicrobial resistance, virulence, genetic traits, and strategies for combating this emerging opportunistic pathogen
Microbiological Research ( IF 6.7 ) Pub Date : 2024-02-22 , DOI: 10.1016/j.micres.2024.127652
Ciro César Rossi , Faizan Ahmad , Marcia Giambiagi-deMarval

, a key species of the genus, holds significant importance in healthcare-associated infections, due to its notable resistance to antimicrobials, like methicillin, and proficient biofilms-forming capabilities. This coagulase-negative bacterium poses a substantial challenge in the battle against nosocomial infections. Recent research has shed light on genomic plasticity, unveiling genetic elements responsible for antibiotic resistance and their widespread dissemination within the genus. This review presents an updated and comprehensive overview of the clinical significance and prevalence of , underscores its zoonotic potential and relevance in the one health framework, explores crucial virulence factors, and examines genetics features contributing to its success in causing emergent and challenging infections. Additionally, we scrutinize ongoing studies aimed at controlling spread and alternative approaches for combating it.

中文翻译:

溶血葡萄球菌:关于医院感染、抗菌素耐药性、毒力、遗传性状以及对抗这种新兴机会性病原体的策略的最新综述

是该属的一个关键物种,由于其对甲氧西林等抗菌药物具有显着的耐药性,并且具有强大的生物膜形成能力,因此在医疗保健相关感染中具有重要意义。这种凝固酶阴性细菌对对抗医院感染构成了重大挑战。最近的研究揭示了基因组的可塑性,揭示了导致抗生素耐药性及其在属内广泛传播的遗传元件。这篇综述对 的临床意义和患病率进行了更新和全面的概述,强调了其人畜共患病的潜力和在单一健康框架中的相关性,探讨了关键的毒力因素,并检查了有助于其成功引起紧急和具有挑战性的感染的遗传学特征。此外,我们还仔细审查正在进行的旨在控制传播的研究以及对抗传播的替代方法。
更新日期:2024-02-22
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