Point-of-care testing (POCT) biosensors are rapidly developing in recent years because of the urgent needs for rapid test and home test. Among various types of POCT biosensors, paper-based biosensors have occupied large market share owing to the advantages of cost-effectiveness, portability and simplicity. To further meet the increasing requirement of POCT in various application scenes, the functionalization of paper is highly demanded. Metal-organic framework (MOF), a multifunctional porous material, is introduced in the design of paper-based biosensors, significantly improving the sensing property and application potential. This review provides a summary of the recent advances and emerging trends of MOF-functionalized paper-based biosensors (MOF@paper), including different types of substrates, fabrication methods, detection mechanisms and applications. On account of the multifunctionality and superior performance of MOF@paper biosensors, this field should possess promising prospect in scientific researches, translational medicine and clinical applications.

中文翻译：

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MOF 功能化纸基生物传感器：制造、机制和应用

由于快速检测和家庭检测的迫切需求，即时检测（POCT）生物传感器近年来迅速发展。在各种类型的POCT生物传感器中，纸基生物传感器凭借成本效益、便携性和简单性的优势占据了很大的市场份额。为了进一步满足POCT在各种应用场景中日益增长的需求，对纸张的功能化提出了很高的要求。金属有机框架（MOF）这种多功能多孔材料被引入纸基生物传感器的设计中，显着提高了传感性能和应用潜力。本综述总结了 MOF 功能化纸基生物传感器（MOF@paper）的最新进展和新兴趋势，包括不同类型的基材、制造方法、检测机制和应用。由于MOF@纸生物传感器的多功能性和优越性能，该领域在科学研究、转化医学和临床应用方面具有广阔的前景。