Beta hypersynchrony was recently introduced into clinical practice in Parkinson’s disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200–500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication “off” state. Coupling between beta power and HFOs is known to be a correlate of the PD “off” state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

Beta 超同步最近被引入帕金森病 (PD) 的临床实践，以确定最佳刺激接触和自适应深部脑刺激 (aDBS) 传感。然而，许多其他振荡病伴随该疾病，并且β功率传感可能并不适合所有患者。这项工作的目的是研究 β 功率相位幅度耦合 (PAC) 与高频振荡 (HFO) 的潜在临床用途。记录并分析 PD 患者的丘脑底核 (STN) 局部场电位 (LFP)（n  = 19）。Beta 功率和 HFO 在静息状态下进行评估；然后研究 PAC 并与电极接触位置、结构连接性和药物状态进行比较。在所有受试者中均观察到 Beta-HFO PAC（主要在 200-500 Hz 范围内）。与 β 功率和 HFO 相比，PAC 在 STN 的运动部分中可更具体地检测到。此外，PAC 的存在更好地对应于基于临床效果的刺激设置。PAC 对症状和多巴胺能治疗的偏侧性也很敏感，其中较大的 PAC 簇反映了更受影响的一侧和药物“关闭”状态。众所周知，β 功率和 HFO 之间的耦合与 PD“关闭”状态相关。Beta-HFO PAC 似乎比 beta 功率本身更敏感，并且对于选择最佳临床刺激接触更有帮助，也可能作为 aDBS 未来的潜在输入信号。