Three previously undescribed aporphine alkaloids, phaeanthuslucidines E–G, one previously undescribed naphthoquinone derivative, phaeanthusnaphthoquinone, and three known compounds were isolated from an EtOAc extract of the leaves of Oliv. The structures of all previously undescribed compounds were established through extensive spectroscopic investigations and high-resolution mass spectroscopy. The 6a configuration of phaeanthuslucidines E–G was assigned by comparing their ECD spectra and specific rotation values with the reported known compounds. Some isolated compounds were evaluated for their -glucosidase inhibitory activity. Among these compounds, phaeanthuslucidine E showed the highest -glucosidase inhibitory activity with an IC value of 17.9 ± 0.4 μM. The molecular docking of phaeanthuslucidine E was further studied.

中文翻译：

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来自 Phaeanthus lucidus Oliv 叶子的阿朴啡生物碱和萘醌衍生物。及其α-葡萄糖苷酶抑制活性

从 Oliv 叶子的 EtOAc 提取物中分离出三种先前未描述的阿朴啡生物碱（phaeanthuslucidines E-G）、一种先前未描述的萘醌衍生物（phaeanthusnaphthoquinone）和三种已知化合物。所有先前未描述的化合物的结构都是通过广泛的光谱研究和高分辨率质谱确定的。通过将 ECD 光谱和比旋光度值与已报道的已知化合物进行比较，确定了 phaeanthuslucidines E-G 的 6a 构型。评估了一些分离的化合物的β-葡萄糖苷酶抑制活性。在这些化合物中，phaeanthuslucidine E 显示出最高的 β-葡萄糖苷酶抑制活性，IC 值为 17.9 ± 0.4 μM。进一步研究了Phaeanthuslucidine E的分子对接。