Functional imaging studies and clinical evidence indicate that cortical areas relevant to social cognition are closely integrated with evolutionarily conserved basal forebrain structures and neighboring regions, enabling human attachment and affiliative emotions. The neural circuitry of human affiliation is continually being unraveled as functional magnetic resonance imaging (fMRI) becomes increasingly prevalent, with studies examining human brain responses to various attachment figures. However, previous fMRI meta-analyses on affiliative stimuli have encountered challenges, such as low statistical power and the absence of robustness measures. To address these issues, we conducted an exhaustive coordinate-based meta-analysis of 79 fMRI studies, focusing on personalized affiliative stimuli, including one's infants, family, romantic partners, and friends. We employed complementary coordinate-based analyses (Activation Likelihood Estimation and Signed Differential Mapping) and conducted a robustness analysis of the results. Findings revealed cluster convergence in cortical and subcortical structures related to reward and motivation, salience detection, social bonding, and cognition. Our study thoroughly explores the neural correlates underpinning affiliative responses, effectively overcoming the limitations noted in previous meta-analyses. It provides an extensive view of the neural substrates associated with affiliative stimuli, illuminating the intricate interaction between cortical and subcortical regions. Our findings significantly contribute to understanding the neurobiology of human affiliation, expanding the known human attachment circuitry beyond the traditional basal forebrain regions observed in other mammals to include uniquely human isocortical structures.

中文翻译：

---

人类依恋的扩展神经结构：基于功能磁共振成像坐标的依恋研究荟萃分析

功能成像研究和临床证据表明，与社会认知相关的皮质区域与进化上保守的基底前脑结构和邻近区域紧密结合，从而实现了人类依恋和亲和情感。随着功能性磁共振成像 (fMRI) 的日益普及，人类依恋的神经回路不断被揭示，研究检查了人类大脑对各种依恋对象的反应。然而，之前对附属刺激的功能磁共振成像荟萃分析遇到了挑战，例如统计功效低和缺乏稳健性措施。为了解决这些问题，我们对 79 项 fMRI 研究进行了详尽的基于坐标的荟萃分析，重点关注个性化的附属刺激，包括婴儿、家人、浪漫伴侣和朋友。我们采用了互补的基于坐标的分析（激活似然估计和符号差分映射）并对结果进行了稳健性分析。研究结果揭示了与奖励和动机、显着性检测、社会联系和认知相关的皮质和皮质下结构的聚类趋同。我们的研究彻底探索了支持亲和反应的神经相关性，有效克服了之前荟萃分析中指出的局限性。它提供了与附属刺激相关的神经基质的广泛视图，阐明了皮质和皮质下区域之间复杂的相互作用。我们的研究结果极大地有助于理解人类归属的神经生物学，将已知的人类依恋回路扩展到在其他哺乳动物中观察到的传统基底前脑区域之外，以包括独特的人类同皮质结构。