Sleep is an instinct behavior, and its significance and functions are still an enigma. It is expressed throughout one's life and its loss affects psycho-somatic and physiological processes. We had proposed that it might maintain a fundamental property of the neurons and the brain. In that context, it was shown that sleep, rapid eye movement sleep (REMS) in particular, by regulating noradrenaline (NA), maintains the brain excitability. It was also reported that sleep-loss affected memory, reaction time and decision-making ability among others. However, as there was lack of clarity on the cause-and-effect relationship as to how the sleep-loss could affect these basic behaviors, their association was questioned and it was difficult to propose a cure or at least ways and means to ameliorate the symptoms. Also, we wanted to conduct the studies in a simpler model system so that conducting future molecular studies might be easier. Hence, using zebrafish as a model we evaluated if sleep-loss affected the basic decision-making ability, a cognitive process and if the effect was induced by NA. Indeed, our findings confirmed that upon sleep-deprivation, the cognitive decision-making ability of the prey zebrafish was compromised to protect itself by running away from the reach of the exposed predator Tiger Oscar (TO) fish. Also, we observed that upon sleep-loss the axonal arborization of the prey zebrafish brain was reduced. Interestingly, the effects were prevented by prazosin (PRZ), an α1-adrenoceptor (AR) antagonist and when the zebrafish recovered from the lost sleep.

中文翻译：

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睡眠不足会破坏斑马鱼的决策能力和神经元细胞形态，其影响是由去甲肾上腺素作用于 α1 肾上腺素受体介导的

睡眠是一种本能行为，其意义和功能至今仍是一个谜。它在人的一生中都有表达，它的丧失会影响心身和生理过程。我们提出它可能保持神经元和大脑的基本特性。在这种情况下，研究表明，睡眠，特别是快速眼动睡眠（REMS），可以通过调节去甲肾上腺素（NA）来维持大脑的兴奋性。据报道，睡眠不足会影响记忆力、反应时间和决策能力等。然而，由于缺乏关于睡眠不足如何影响这些基本行为的因果关系的明确性，它们的关联受到质疑，并且很难提出治疗方法或至少是改善这些行为的方法和手段。症状。此外，我们希望在一个更简单的模型系统中进行研究，以便进行未来的分子研究可能会更容易。因此，我们使用斑马鱼作为模型来评估睡眠不足是否会影响基本决策能力、认知过程以及这种影响是否是由 NA 引起的。事实上，我们的研究结果证实，在睡眠不足时，猎物斑马鱼的认知决策能力会受到影响，为了保护自己，会逃离暴露的捕食者奥斯卡老虎 (TO) 鱼的攻击范围。此外，我们还观察到，在睡眠不足时，猎物斑马鱼大脑的轴突树枝化会减少。有趣的是，当斑马鱼从睡眠中恢复时，哌唑嗪（PRZ）（一种α1-肾上腺素受体（AR）拮抗剂）可以阻止这种影响。