The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression remains elusive. Research conducted in recent decades has uncovered that soluble epoxide hydrolase, a pivotal enzyme in the metabolism of polyunsaturated fatty acids, plays a crucial role in inflammation. Interestingly, this enzyme is intricately linked to the development of both pain and depression. With this understanding, this review aims to summarize the roles of soluble epoxide hydrolase in pain, depression, and their comorbidity. Simultaneously, we will also explore the underlying mechanisms, providing guidance for future research and drug development.

中文翻译：

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可溶性环氧化物水解酶在疼痛和抑郁合并症中的作用

临床实践中慢性疼痛和抑郁症的共存给患者带来了沉重的社会负担和深远的影响。尽管存在明显的相关性，但慢性疼痛和抑郁症之间共病的潜在机制仍然难以捉摸。近几十年来进行的研究发现，可溶性环氧化物水解酶是多不饱和脂肪酸代谢中的关键酶，在炎症中起着至关重要的作用。有趣的是，这种酶与疼痛和抑郁的发生有着复杂的联系。基于这一认识，本综述旨在总结可溶性环氧化物水解酶在疼痛、抑郁及其合并症中的作用。同时，我们还将探讨其背后的机制，为未来的研究和药物开发提供指导。