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The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix
Matrix Biology ( IF 6.9 ) Pub Date : 2024-02-18 , DOI: 10.1016/j.matbio.2024.02.005
Johanna Lena Schön , Victoria Elisabeth Groß , Willem Berend Post , Alexandra Daum , Daniel Matúš , Johanna Pilz , Rene Schnorr , Susanne Horn , Miriam Bäumers , Stefanie Weidtkamp-Peters , Samantha Hughes , Torsten Schöneberg , Simone Prömel

The extracellular matrix (ECM) is a network of macromolecules that presents a vital scaffold for cells and enables multiple ways of cellular communication. Thus, it is essential for many physiological processes such as development, tissue morphogenesis, homeostasis, the shape and partially the size of the body and its organs. To ensure these, the composition of the ECM is tissue-specific and highly dynamic. ECM homeostasis is therefore tightly controlled by several mechanisms.

中文翻译:

火烈鸟的粘附 GPCR 和 PCP 成分 (FMI-1) 改变身体大小并调节细胞外基质的组成

细胞外基质 (ECM) 是一个大分子网络,为细胞提供了重要的支架,并支持多种细胞通讯方式。因此,它对于许多生理过程至关重要,例如发育、组织形态发生、体内平衡、身体及其器官的形状和部分大小。为了确保这些,ECM 的成分是组织特异性的且高度动态的。因此,ECM 稳态受到多种机制的严格控制。
更新日期:2024-02-18
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