With the advancement of scientific research, an increasing number of studies on metal nanozymes, particularly Au NPs, have been conducted. They possess glucose oxidase (GOD)-like activity and peroxidase (POD)-like activity, with GOD-like activity receiving the most attention. However, there is a lack of research and summary on future trends in Au NPs in biomedical field. Therefore, we conducted a study on the GOD-like activity of Au NPs based on 158 relevant publications downloaded from the Web of Science Core Collection between 2007 and 2023, using citation metrics, authors, nations, institutions, cited references, and keywords. We found that Au NPs were initially utilized for glucose biosensors, glucose detection in human serum, and the detection of other carbohydrates and proteins. Researchers have recently focused on its application in oncotherapy and diabetic wound treatment. In addition to being utilized to treat autoimmune illnesses, inflammation, and other diseases, Au NPs may eventually replace insulin and antibiotics. We anticipate that the use of Au NPs will increase in the future. We hope this study will serve as a guide for future researchers so that Au NPs can be applied more broadly and competently.

中文翻译：

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Au NPs类葡萄糖氧化酶活性的研究进展及未来展望

随着科学研究的进步，对金属纳米酶，特别是Au NPs的研究越来越多。它们具有类葡萄糖氧化酶（GOD）活性和类过氧化物酶（POD）活性，其中类GOD活性最受关注。然而，目前对于Au NPs在生物医学领域的未来发展趋势缺乏研究和总结。因此，我们根据 2007 年至 2023 年间从 Web of Science 核心合集中下载的 158 篇相关出版物，使用引文指标、作者、国家、机构、引用的参考文献和关键词，对 Au NP 的 GOD 样活性进行了研究。我们发现金纳米颗粒最初用于葡萄糖生物传感器、人血清中的葡萄糖检测以及其他碳水化合物和蛋白质的检测。研究人员最近重点关注其在肿瘤治疗和糖尿病伤口治疗中的应用。除了用于治疗自身免疫性疾病、炎症和其他疾病外，金纳米颗粒最终可能会取代胰岛素和抗生素。我们预计金纳米颗粒的使用将来将会增加。我们希望这项研究能够为未来的研究人员提供指导，使金纳米粒子能够得到更广泛、更有效的应用。