Chronic pruritus is a cardinal symptom of atopic dermatitis (AD). The mechanisms underlying atopic itch involve intricate crosstalk among skin, immune components, and neural components. In this review, we explore these mechanisms, focusing on key players and interactions that induce and exacerbate itch. We discuss the similarities and differences between pruritus and pain in patients with AD as well as the relationship between pruritus and factors such as sweat and the skin microbiome. Furthermore, we explore novel targets that could provide significant itch relief in these patients as well as exciting future research directions to better understand atopic pruritus in darker skin types.

中文翻译：

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特应性皮炎瘙痒：抓挠寻求解释


慢性瘙痒是特应性皮炎（AD）的主要症状。特应性瘙痒的潜在机制涉及皮肤、免疫成分和神经成分之间复杂的串扰。在这篇综述中，我们探讨了这些机制，重点关注诱发和加剧瘙痒的关键参与者和相互作用。我们讨论 AD 患者瘙痒和疼痛之间的异同，以及瘙痒与汗液和皮肤微生物组等因素之间的关系。此外，我们还探索了可以显着缓解这些患者瘙痒的新靶标，以及令人兴奋的未来研究方向，以更好地了解深色皮肤类型的特应性瘙痒。