The study objective was to evaluate the association between exposure during pregnancy and the prevalence of biliary atresia (BA) in offspring. This was a hospital-based, case-control study in which cases were infants diagnosed with BA at Johns Hopkins All Children's Hospital from October 2001 to December 2019. Cases were matched 1:4 by age to controls who were randomly selected from a pool of healthy infants hospitalized during the study period for common pediatric diagnoses. Infants were excluded if they had congenital anomalies and/or were non-Florida residents. Gestational exposure levels (cells/liter) were determined from Florida Fish and Wildlife Conservation Commission exposure data at 10- and 50 mile radii from the mother's zip code of residence. Multivariable conditional logistic regression determined odds of BA in offspring in relation to maternal gestational exposure adjusted for infant sex, race/ethnicity, coastal residence, and seasonality. Of 38 cases and 152 controls, no significant inter-group differences were observed for infant race/ethnicity, season of birth, or coastal residence. Median gestational exposure at the 10 mile radius was 0 cells/liter in both groups. A greater proportion of cases had no gestational exposure (63.2 %, = 24) in comparison to controls (37.5 %, = 57; = .04) at a 10 mile radius. At a 50 mile radius, cases had a peak median exposure at 6 months of gestation compared to controls’ peak at 9 months. After adjustment for sex, seasonality, race/ethnicity, and coastal residence, there was no significant association between BA and maximum exposure per trimester of pregnancy observed at a 10- or 50 mile radius. In this matched case-control study, we observed no association between gestational (cells/liter) exposure at a 10- or 50 mile radius from maternal zip code of residence and BA in offspring.

中文翻译：

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毒素和胆道闭锁：短卡伦虫（赤潮）是罪魁祸首吗？

该研究的目的是评估怀孕期间暴露与后代胆道闭锁（BA）患病率之间的关联。这是一项以医院为基础的病例对照研究，其中病例是 2001 年 10 月至 2019 年 12 月在约翰·霍普金斯儿童医院诊断为 BA 的婴儿。病例按年龄按 1:4 与从一组随机选择的对照组进行匹配。研究期间因常见儿科诊断而住院的健康婴儿。如果婴儿有先天异常和/或不是佛罗里达州居民，则被排除在外。妊娠期暴露水平（细胞/升）是根据佛罗里达州鱼类和野生动物保护委员会在距母亲居住邮政编码 10 英里和 50 英里半径处的暴露数据确定的。多变量条件逻辑回归确定了与母亲妊娠暴露相关的后代 BA 几率，并根据婴儿性别、种族/民族、沿海居住地和季节性进行了调整。在 38 例病例和 152 例对照中，在婴儿种族/民族、出生季节或沿海居住地方面没有观察到显着的组间差异。两组在 10 英里半径处的妊娠期暴露中值均为 0 细胞/升。与对照组 (37.5%, = 57; = .04) 相比，在 10 英里半径范围内，没有妊娠期暴露的病例比例更高 (63.2%, = 24)。在 50 英里半径内，病例在妊娠 6 个月时达到中位暴露峰值，而对照组在 9 个月时达到峰值。在对性别、季节性、种族/民族和沿海居住进行调整后，在 10 或 50 英里半径范围内观察到的 BA 与怀孕每个三个月的最大暴露量之间没有显着相关性。在这项匹配的病例对照研究中，我们观察到距母亲居住地邮政编码 10 或 50 英里半径范围内的妊娠期（细胞/升）暴露与后代的 BA 之间没有关联。