Osteoarthritis (OA) is the most common type of joint disease and the leading cause of chronic disability among older adults. As an important component of the joint, synovium influences the inflammatory and degenerative process of OA. This study found that miRNA 182 (miR-182) in synovium-specific exosomes can modulate inflammation and apoptotic signaling. It also regulated different biological functions to promote the progression of OA. Experiments based on rat OA model and synovium samples from OA patients, we found that synovium-derived miR-182 regulates inflammatory response in the early stage of OA by regulating the expression level of forkhead box O-3 (FOXO3). However, the expression of miR-182 was significantly increased in synovial tissue of advanced OA, which was involved in the apoptotic signal of severe OA. These findings suggest that miR-182 may directly regulate OA progression by modulating FOXO3 production inflammation, and apoptosis.

中文翻译：

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滑液组织特异性外泌体通过 miR-182 参与骨关节炎微环境的双重变化

骨关节炎（OA）是最常见的关节疾病类型，也是老年人慢性残疾的主要原因。滑膜作为关节的重要组成部分，影响着OA的炎症和退行性过程。这项研究发现滑膜特异性外泌体中的 miRNA 182 (miR-182) 可以调节炎症和细胞凋亡信号传导。它还调节不同的生物学功能以促进OA的进展。基于大鼠OA模型和OA患者滑膜样本的实验，我们发现滑膜来源的miR-182通过调节叉头盒O-3（FOXO3）的表达水平来调节OA早期的炎症反应。然而，miR-182在晚期OA的滑膜组织中表达显着升高，其参与了严重OA的细胞凋亡信号。这些发现表明 miR-182 可能通过调节 FOXO3 产生、炎症和细胞凋亡来直接调节 OA 进展。