The expression of costimulatory molecules such as MHC-II, CD86 and CD83 on dendritic cells (DCs) are strongly regulated during cellular activation. Ubiquitination of some of these markers by the E3 ubiquitin ligase MARCH-I affects the maturation state of DCs and subsequently modulates immune responses. The effects of MARCH-I gene overexpression on the functional activity of human DCs is not well understood.

中文翻译：

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MARCH-I：树突状细胞成熟的负调节因子


树突状细胞 (DC) 上 MHC-II、CD86 和 CD83 等共刺激分子的表达在细胞激活过程中受到强烈调节。 E3 泛素连接酶 MARCH-I 对其中一些标记物的泛素化会影响 DC 的成熟状态，并随后调节免疫反应。 MARCH-I 基因过表达对人类 DC 功能活性的影响尚不清楚。