There are many different approaches to drug discovery in academia, some of which are based broadly on the industrial model of discovering novel targets and then conducting screening within academic drug discovery centres to identify hit molecules. Here we describe our approach to drug discovery, which makes more efficient use of the capabilities and resources of the different stakeholders. Specifically, we have created a large portfolio of drug projects and conducted small amounts of derisking work to ensure projects are investment ready. In this feature we will describe this model, including its limitations and advantages, since we believe the ideas and concepts will be of interest to other academic institutions and consortia.

中文翻译：

---

学术药物发现：挑战与机遇

学术界有许多不同的药物发现方法，其中一些方法广泛基于发现新靶标的工业模型，然后在学术药物发现中心进行筛选以识别命中分子。在这里，我们描述了我们的药物发现方法，该方法可以更有效地利用不同利益相关者的能力和资源。具体来说，我们创建了大量药物项目组合，并进行了少量的去风险工作，以确保项目做好投资准备。在本专题中，我们将描述该模型，包括其局限性和优点，因为我们相信其他学术机构和财团会对这些想法和概念感兴趣。