Diep et al. identify the molecular machinery of the yeast vacuole lipid droplet contact site vCLIP, which comprises two Vac8-dependent tethers, Ldo16 and Ldo45, and the phosphatidylinositol transfer protein Pdr16. vCLIP abundance and molecular composition are metabolically controlled, and vCLIP-dependent vacuole tethering is required for selective lipid droplet autophagy (lipophagy).

中文翻译：

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酵母中液泡和脂滴之间代谢控制的接触位点

迪普等人。鉴定了酵母液泡脂滴接触位点 vCLIP 的分子机制，该位点包含两个 Vac8 依赖性连接链 Ldo16 和 Ldo45，以及磷脂酰肌醇转移蛋白 Pdr16。 vCLIP 丰度和分子组成受代谢控制，并且选择性脂滴自噬（脂噬）需要依赖 vCLIP 的液泡束缚。